Ionomycin

$57.00$968.00

Formal Name
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2’R,5S,5’S)-octahydro-5′-[(1R)-1-hydroxyethyl]-2,5′-dimethyl[2,2′-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid
Molecular Formula
C41H72O9
Formula Weight
709.0
Purity
≥95%
Formulation
A solution in ethanol
Solubility
  • DMF: 2.5 mg/ml
  • DMSO: 1.4 mg/ml
  • Ethanol: 20 mg/ml
  • Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
λmax
277 nm
Origin
Bacteria/Streptomyces conglobatus
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
SKU: N/A Category:

Description

Ionomycin For Sale | Ionomycin Online | Buy Ionomycin | Ionomycin Calcium

Ionomycin is a calcium ionophore obtained from S. conglobatus. It triggers the release of calcium ions within X. laevis oocytes at a concentration of 5 µM. In isolated human neutrophils, Ionomycin (5 µM) promotes the formation of neutrophil extracellular traps (NETs). Ionomycin Online is often combined with phorbol 12-myristate 13-acetate to induce T cell proliferation and activation, as well as stimulate cytokine production in macrophages in vitro.

In the intricate world of cell signaling and molecular biology, a fascinating compound called ionomycin has emerged as a key player in understanding cellular processes. Ionomycin, a potent ionophore, has captured the attention of scientists and researchers for its unique ability to manipulate cellular calcium levels, paving the way for a deeper understanding of various biological phenomena. In this blog post, we’ll dive into the captivating realm of ionomycin, exploring its structure, mechanisms of action, and the diverse applications that make it an invaluable tool in scientific research.

Ionomycin 101:

Ionomycin Online, derived from Streptomyces conglobatus, is a polyether antibiotic with a distinctive structure that sets it apart. Comprising a macrocyclic lactone backbone, ionomycin possesses high affinity for divalent cations, particularly calcium ions (Ca2+). Its ability to selectively transport calcium across cell membranes makes it a powerful tool for researchers seeking to modulate intracellular calcium concentrations.

Mechanisms of Action:

The cellular symphony orchestrated by ionomycin begins with its interaction with the lipid bilayer of cell membranes. Once bound, ionomycin forms complexes with calcium ions, facilitating their transport across the cell membrane. This unique property allows researchers to artificially elevate intracellular calcium levels, leading to a cascade of cellular responses.

One of the primary mechanisms involves ionomycin inducing the release of calcium from intracellular stores, such as the endoplasmic reticulum. This surge in calcium concentration triggers downstream signaling pathways, influencing cellular processes such as gene expression, secretion, and cell differentiation.

Applications in Research:

The versatility of ionomycin has made it an indispensable tool in various fields of research. Here are some key applications:

  1. Cell Signaling Studies:

    • Ionomycin Online is widely used to investigate the intricacies of cell signaling pathways, especially those involving calcium-dependent processes. Researchers can manipulate intracellular calcium concentrations to study the effects on cellular responses.
  2. Immunology and Inflammation Research:

    • In immunology, ionomycin has been employed to activate immune cells and study their responses. Its ability to induce cytokine release and cellular activation makes it valuable in understanding inflammatory processes.
  3. Neuroscience:

    • Neuroscientists leverage ionomycin to study neuronal function and synaptic transmission. By modulating calcium levels, researchers gain insights into neurotransmitter release and the mechanisms underlying synaptic plasticity.
  4. Cell Differentiation and Apoptosis:

    • Ionomycin Online plays a crucial role in studies related to cell fate determination and apoptosis. Researchers use it to trigger differentiation in certain cell types and to induce programmed cell death, providing valuable insights into these fundamental biological processes.

Conclusion:

In the ever-evolving landscape of scientific exploration, ionomycin stands as a beacon, illuminating the complexities of cellular communication and function. Its ability to manipulate calcium levels has opened new avenues of research, unraveling the mysteries of cell signaling, immunology, and neuroscience. As scientists continue to delve into the secrets of ionomycin, it remains a powerful tool, contributing to our understanding of the intricate dance of molecules within the cellular symphony.

Additional information

Quantity

1 mg, 5 mg, 10 mg, 25 mg

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