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3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative hallucinogen of the aryl cyclohexylamine magnificence associated with phencyclidine (PCP) which has been offered on line as a fashion dressmaker drug. It acts specifically as an NMDA receptor antagonist, though it has additionally been discovered to engage with the sigma σ1 receptor and the serotonin transporter. The drug does now no longer own any opioid hobby nor does it act as a dopamine reuptake inhibitor

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What is 3-MeO-PCP ? |  Buy 3-meo-pcp online

buy 3-meo-pcp . 3-Methoxyphencyclidine (additionally referred to as 3-MeO-PCP) is a lesser-recognized novel dissociative substance of the arylcyclohexylamine class. 3-MeO-PCP is a spinoff of phencyclidine (PCP) and is chemically associated with materials like methoxetamine and 3-MeO-PCE. It produces its results through the use of blocking NMDA receptors in the brain. 3 meo pcp street name

3-MeO-PCP turned into first synthesized in 1979 in research on phencyclidine (PCP) derivatives. However, its hobby in human beings turned into now no longer defined till 1999 whilst a chemist the using the pseudonym John Q. Beagle mentioned qualitative similarities to PCP at the side of similar potency. In 2009, it commenced to be mentioned on online boards along with bluelight.ru and turned into made-to-be-had on the market at the studies chemical compounds market. buy 3-meo-pcp

Like different arylcyclohexylamines, 3-MeO-PCP induces a nation stated as “dissociative anesthesia”, even though the volume to which this takes place is mentioned to be exceedingly dose-established and variable in its outcomes. It is normally taken orally and nasally, even though it can additionally be smoked and injected.

It has been stated for its diffused arise and tendency to provide delusions of sobriety, could cause compulsive redosing. buy 3-meo-pcp

Very few statistics exist for the pharmacology, metabolism, and toxicity of 3-MeO-PCP. Due to its mighty hallucinogenic outcomes and absence of studies, it’s miles strongly suggested to apply use damage discount practices if the usage of this substance. 3 meo pcp psychonaut

Smoked
⇣ Oral
Dosage
Threshold 2 mg
Light 4 – 8 mg
Common 8 – 15 mg
Strong 15 – 25 mg
Heavy 25 mg + Heavy doses may result in psychosis and mania.[4]
Duration
Total 4 – 8 hours
Onset 30 – 90 minutes
Come up 45 – 120 minutes
Peak 2 – 3 hours
Offset 1 – 2 hours
After effects 4 – 48 hours

 Chemistry of 3-MeO-PCP — 3-MeO-PCP HCL Powder

3-Methoxyphencyclidine, or 3-MeO-PCP, is an artificial dissociative of the arylcyclohexylamine class. 3-MeO-PCP consists of cyclohexane, a six-member saturated ring, bonded to 2 extra stimulants at R1. One of that stimulants is a piperidine ring, a nitrogenous six-member ring, bonded at its nitrogen group. The different ring is a fragrant phenyl ring, substituted at R3 with a methoxy group.

3-MeO-PCP is a PCP by-product and structurally analogous to 4-MeO-PCP.

— 3MeOPCP Pharmacology — Achat 3-MEO-PCP

3MeOPCP acts as an NMDA receptor antagonist. A unique subtype of glutamate receptor, NMDA (N-Methyl-D-Aspartate), modulates the transmission of electrical indicators among neurons in the mind and spinal cord; for the indicators to pass, the receiver must be open. buy 3-meo-pcp

Dissociative inhibit the everyday functioning NMDA receptors via way of means of binding to and blocking off them. This disruption of neural community interest results in a lack of everyday cognitive and affective processing, psychomotor functioning, anesthesia, and possibly the pair of a “khole”. buy 3-meo-pcp

buy 3-meo-pcp . 3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter (SERT), forty-two nM for the sigma-1 receptor, and 2960 nM for the H1 receptor. It binds to the NMDA receptor with better affinity than PCP and has the best affinity of the 3 isomeric anisyl-substitutions, accompanied via way of means of 2-MeO-PCP and 4-MeO-PCP.

Although 3-MeO-PCP became as soon as claimed to own opioid or dopaminergic interest, this supposition is contradicted via way of means of records displaying 3-MeO-PCP to be a robust and selective ligand for the NMDA receptor without considerable affinity for the µ-opioid receptor or dopamine transporter.

3-MeO-PCP became preceded via way of means of the much less robust dissociative 4-MeO-PCP and primary have become to be had as a studies chemical in 2011. buy 3-meo-pcp

— Subjective consequences or effects of 3-MeO-PCP —

3-MeO-PCP is typically defined as being greater stimulating and much less immobilizing than different dissociative together with ketamine or MXE.

buy 3-meo-pcp . At decreased doses, it could result in sensory improvements together with shade action enhancement, acuity enhancement, tactile enhancement, auditory enhancement, and physical manipulation enhancement. At medium to excessive doses, it gives sensory suppressions together with tactile suppression, motor manipulation loss, auditory suppression, and acuity suppression.

Based on a massive quantity of enjoying reports, it seems to be substantially much more likely to result in mania, delusions, and psychosis than different dissociative (probably because of its surprisingly excessive potency, compulsivity, and erratic dose-response). 3 meo pcp trip report

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